<?xml version="1.0"?>
<edsp version="3.1" about_me="http://ycmi.med.yale.edu/EAVCR/EDSP" source="Olfactory Receptors Database">
  <source>
    <type>eav/cr</type>
    <name>Data Store:SenseLab</name>
    <location>ordb.biotech.ttu.edu</location>
    <date>4/6/2026 10:24:23 PM</date>
    <query_method>GET</query_method>
    <query_parameter>o=21787</query_parameter>
  </source>
  <metadata type="partial" time="0.0156254999892553">
    <datatypes>
      <datatype id="B" name="Boolean" xml_datatype="xs:boolean" />
      <datatype id="C" name="Object/Ref" xml_datatype="xs:long" />
      <datatype id="D" name="Datetime" xml_datatype="xs:dateTime" />
      <datatype id="F" name="Formula(only)" xml_datatype="xs:anyType" />
      <datatype id="H" name="Hierarchy(p)" xml_datatype="xs:long" />
      <datatype id="I" name="Integer" xml_datatype="xs:long" />
      <datatype id="M" name="Memo" xml_datatype="xs:string" />
      <datatype id="R" name="Real" xml_datatype="xs:double" />
      <datatype id="S" name="String" xml_datatype="xs:string" />
      <datatype id="V" name="Object/Value" xml_datatype="xs:long" />
      <datatype id="W" name="Object/Ref(MC)" xml_datatype="xs:long" />
      <datatype id="Y" name="Binary" xml_datatype="xs:base64Binary" />
    </datatypes>
    <metadata_ontology>
      <sem_type_atts>
        <sta id="s17" umls_tui="T017" name="Anatomical Structure" />
        <sta id="s22" umls_tui="T022" name="Body System" />
        <sta id="s23" umls_tui="T023" name="Body Part, Organ, or Organ Component" />
        <sta id="s29" umls_tui="T029" name="Body Location or Region" />
        <sta id="s30" umls_tui="T030" name="Body Space or Junction" />
        <sta id="s77" umls_tui="T077" name="Conceptual Entity" />
      </sem_type_atts>
      <sem_rel_types>
        <srt id="s2" umls_tui="CHD" name="Class is parent of Attribute" />
      </sem_rel_types>
      <sem_rel_att />
    </metadata_ontology>
    <database id="d9" name="hbpdb" caption="HBPDB" caption_long="Human Brain Project Database" description="This database provides search tools to aid the user in finding information contained within the projects participating in the Human Brain Project." main_class="65" version="17" version_date="7/30/2003 11:28:22 AM">
      <class id="c65" name="projects" caption="Projects" description="Contains information about participating projects within HBP" object_description_hide="false" type="E" is_concept="false" host_concepts="false" uid="" version="2" version_date="3/17/2003 12:41:02 PM">
        <att id="a215" dt_id="S" sn="1" name="url" caption="URL" description="" width="80" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="4" version_date="3/28/2003 11:18:04 AM" />
        <att id="a216" dt_id="C" sn="2" name="category" caption="Category" description="" ref_class="c66" ref_class_name="category" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="2" version_date="3/5/2003 10:49:10 AM" />
        <att id="a217" dt_id="C" sn="3" name="scale" caption="Scale" description="Spatial scale or domain" ref_class="c67" ref_class_name="scale" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" sta_ids="s17,s22,s23,s29,s30" version="1" version_date="3/13/2003 5:15:12 PM" />
        <att id="a218" dt_id="C" sn="4" name="type" caption="Type" description="Theoretical or experimental or both" ref_class="c69" ref_class_name="type" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" sta_ids="s77" version="1" version_date="3/14/2003 11:35:08 AM" />
        <att id="a219" dt_id="C" sn="5" name="species" caption="Species" description="Species of animal(s)" ref_class="c68" ref_class_name="species" mi="true" is_concept="false" host_concepts="false" uid="C0449420" srt_id="s" sra_id="s" version="1" version_date="3/14/2003 11:35:49 AM" />
        <att id="a222" dt_id="C" sn="6" name="person_role" caption="Person; Role" description="People in the projects" ref_class="c76" ref_class_name="person_role" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="5" version_date="5/15/2003 5:48:48 PM" />
        <att id="a223" dt_id="M" sn="7" name="projectDescription" caption="Project Description" description="" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="2" version_date="3/20/2003 1:13:22 PM" />
        <att id="a233" dt_id="C" sn="8" name="project_database" caption="Database" description="Databases are selected from the database class of HBPDB" ref_class="c74" ref_class_name="database" mi="true" is_concept="false" host_concepts="false" uid="C0993637" srt_id="s2" sra_id="s" version="1" version_date="5/15/2003 10:42:26 AM" />
        <att id="a235" dt_id="C" sn="9" name="tool" caption="Shared Tool(s)" description="These shared tools are publicly accesible over the web." ref_class="c75" ref_class_name="tool" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="5/15/2003 11:17:18 AM" />
      </class>
    </database>
  </metadata>
  <data time="0.0312514000106603">
    <data_database db_id="d9">
      <data_class class_id="c65" version="2">
        <object id="o21787" name="Wavelets, fractals and fMRI of brain adaptivity" description="Developing new wavelet-based methods of data analysis for functional magnetic imaging (fMRI) and applying these methods to investigate normal age-related changes in neurotransmitter mechanisms for brain systems function." uid="" version="12" version_date="5/19/2003 6:03:21 PM">
          <att_value att_id="a215" value="http://www-bmu.psychiatry.cam.ac.uk" />
          <att_value att_id="a216" value="o20733" serial_no="0" value_object_name="Images" />
          <att_value att_id="a216" value="o20963" serial_no="0" value_object_name="Mathematical software" />
          <att_value att_id="a216" value="o21791" serial_no="0" value_object_name="Pharmacology" />
          <att_value att_id="a216" value="o20952" serial_no="0" value_object_name="Protocols" />
          <att_value att_id="a217" value="o20736" serial_no="0" value_object_name="Brain" />
          <att_value att_id="a218" value="o20748" serial_no="0" value_object_name="Experiment" />
          <att_value att_id="a218" value="o20749" serial_no="0" value_object_name="Theory" />
          <att_value att_id="a219" value="o20744" serial_no="0" value_object_name="human" />
          <att_value att_id="a222" value="o21872" serial_no="0" value_object_name="Cinly Ooi; Web development" />
          <att_value att_id="a222" value="o21807" serial_no="0" value_object_name="Ed Bullmore; PI" />
          <att_value att_id="a223" value="Our focus on wavelet-based methodological development is motivated by the potential for wavelets to provide a multiresolutional analysis of non-stationary signals and images. Preliminary work by our group has highlighted the statistical convenience of the whitening or decorrelating property of the wavelet transform applied to signals with fractal or 1/f-type error structure. For example, we have proposed a &quot;wavestrapping&quot; (bootstrapping in the wavelet domain) technique for resampling 1-dimensional fMRI time series [1] and we have shown that it is possible efficiently to estimate the signal and noise parameters of the general linear model in the wavelet domain - a technique we called wavelet-generalised least squares [2]. In the course of the project, we intend to develop these ideas further in several ways including: i) an extension of multiresolutional analysis to 2- and 3-dimensional spatial maps; ii) an evaluation of connectivity analysis in the wavelet domain; iii) application and evaluation of a wavelet-based algorithm for multiresolutional image registration in the context of second-level (group and factorial) analysis of fMRI data; and iv) application of wavelet-based estimators for fractal dimension or 1/f spectral exponent of fMRI time series.   &#xD;&#xA; &#xD;&#xA;We have chosen to conduct a pharmacological fMRI study as the main neuroscience component of the project for two main reasons: i) such studies provide a suitably complex and challenging context in which to evaluate the merits of new methods in direct comparison to existing alternatives; and ii) we have a long term interest in the potential value of pharmacological fMRI as a tool for assaying changes in transmitter-dependent brain function in the course of normal development. In particular we are interested in the hypothesis that some aspects of adaptivity and connectivity of large scale brain systems may be mediated by specific transmitter systems. Some prior work in support of this hypothesis includes our fMRI study of normal elderly volunteers, scanned following treatment with a variety of generic compounds, which indicated that adaptivity to task difficulty (load) in a fronto-striatal system might be specifically susceptible to dopaminergic and cholinergic (but not GABAergic) drugs and that functional and effective connectivity of the striatum was specifically modulated by dopaminergic drugs [3,4].&#xD;&#xA;&lt;br&gt;&lt;br&gt;&#xD;&#xA;1) Bullmore ET et al (2001) Colored noise and computational inference in neurophsyiological (fMRI) time series analysis: resampling methods in time and wavelet domains. Human Brain Mapping 12, 61-78.&#xD;&#xA;&lt;br&gt;&#xD;&#xA;2) Fadili J &amp; Bullmore ET (2002) Wavelet-generalized least squares: a new BLU estimator of linear regression models with 1/f errors. NeuroImage 15, 217-232.&#xD;&#xA;&lt;br&gt;&#xD;&#xA;3) Bullmore ET et al (2003) Practice and difficulty evoked anatomically and pharmacologically dissociable brain activation dynamics. Cerebral Cortex 13, 144-154.&#xD;&#xA;&lt;br&gt;&#xD;&#xA;4) Honey GD et al (2003) Dopaminergic drug effects on physiological connectivity in a human cortico-striato-thalamic system. Brain, in press.&#xD;&#xA;" />
          <att_value att_id="a235" value="o21996" serial_no="0" value_object_name="BAMM" />
        </object>
      </data_class>
    </data_database>
  </data>
</edsp>

