<?xml version="1.0"?>
<edsp version="3.1" about_me="http://ycmi.med.yale.edu/EAVCR/EDSP" source="Olfactory Receptors Database">
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    <type>eav/cr</type>
    <name>Data Store:SenseLab</name>
    <location>ordb.biotech.ttu.edu</location>
    <date>4/6/2026 6:32:55 PM</date>
    <query_method>GET</query_method>
    <query_parameter>o=1390</query_parameter>
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    <datatypes>
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    <metadata_ontology>
      <sem_type_atts>
        <sta id="s192" umls_tui="T192" name="Receptor" />
      </sem_type_atts>
      <sem_rel_types>
        <srt id="s6" umls_tui="AQ" name="Attribute qualifies Class" />
      </sem_rel_types>
      <sem_rel_att>
        <sra id="s18" umls_tui="" name="is found in" />
      </sem_rel_att>
    </metadata_ontology>
    <database id="d1" name="neurondb" caption="NeuronDB" caption_long="Neuron Database" description="NeuronDB provides a dynamically searchable database of three types of neuronal properties: voltage gated conductances, neurotransmitter receptors, and neurotransmitter substances. It contains tools that provide for integration of these properties in a given type of neuron and comparison of properties across different types of neurons." main_class="18" version="7" version_date="3/3/2009 11:41:40 AM">
      <class id="c25" name="neuronalreceptors" caption="Neuronal Receptors" description="Receptors in specific neuron compartments. (ncr)" object_description_hide="false" type="A" is_concept="false" host_concepts="false" uid="" version="7" version_date="9/25/2015 1:26:36 AM">
        <att id="a108" dt_id="B" sn="1" name="property_present" caption="Property present" description="    Is the property present" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="4/2/2002 12:00:02 AM" />
        <att id="a60" dt_id="C" sn="2" name="Neuron" caption="Neuron" description="" ref_class="c18" ref_class_name="neuron" mi="false" required="Yes" is_concept="true" host_concepts="true" uid="C0027882" srt_id="s" sra_id="s" version="1" version_date="4/2/2002 12:00:02 AM" />
        <att id="a47" dt_id="V" sn="3" name="CF_Compartment" caption="CF-Compartment" description="" ref_class="c20" ref_class_name="canonical_compartments" mi="false" required="Yes" is_concept="true" host_concepts="true" srt_id="s" sra_id="s" version="2" version_date="7/8/2003 12:02:16 AM" />
        <att id="a49" dt_id="C" sn="4" name="receptor" caption="Receptor" description="Specific receptor for this cell-compartment" ref_class="c9" ref_class_name="receptor" mi="false" required="Yes" is_concept="true" host_concepts="true" uid="C0597357" srt_id="s6" sra_id="s18" sta_ids="s192" version="3" version_date="10/8/2002 2:32:20 PM" />
        <att id="a50" dt_id="S" sn="5" name="connectnote" caption="Connect Note" description="" width="500" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="9" version_date="3/25/2017 10:05:18 AM" />
        <att id="a677" dt_id="C" sn="7" name="pub_facts" caption="Publication facts" description="" ref_class="c195" ref_class_name="pub_facts" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="6/7/2018 11:24:45 AM" />
      </class>
    </database>
  </metadata>
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    <data_database db_id="d1">
      <data_class class_id="c25" version="7">
        <object id="o1390" name="CA3-DAD-AMPA" description="" uid="" version="1" version_date="4/12/2002 6:06:42 PM">
          <att_value att_id="a108" value="-1" />
          <att_value att_id="a60" value="o259" value_object_name="Hippocampus CA3 pyramidal GLU cell" />
          <att_value att_id="a47" value="o293" value_object_name="Distal apical dendrite" />
          <att_value att_id="a49" value="o205" value_object_name="AMPA" />
          <att_value att_id="a50" value="Perforant pathway entorhinal pyramidal neuron terminals (T)" />
          <att_value att_id="a677" value="o242606" serial_no="1" value_object_name="Quantitative autoradiography has been used to localize [3H]AMPA binding sites. It was found that AMPARs are found in a high concentration in the hippocampus relative to other areas in the brain. In CA3, labeling was substantially heavier in s. pyramidale than in s.radiatum and s. lacunosum-moleculare " />
          <att_value att_id="a677" value="o242754" serial_no="2" value_object_name="The physiology of these receptors has been studied in outside-out patches from the proximal apical dendrites. It was found that a CNQX-sensitive component of the synaptic current evoked by fast aplication of glutamate could be isolated (and was presumed to be the result of AMPA channel opening). It was calculated that AMPA channels had a mean elementary conductance of 10 pS (estimated by non-stationary fluctuation analysis) and was found that the channels had a low permeability to Ca2+. The reversal potential for AMPA receptors was found to be about 0 mV with an almost linear peak current-voltage relationship " />
          <att_value att_id="a677" value="o242641" serial_no="3" value_object_name="see also " />
          <att_value att_id="a677" value="o242478" serial_no="4" value_object_name="It has also been found that CNQX does not block the intracellular calcium concentration increase normally associated with stratum lucidum stimulation " />
          <att_value att_id="a677" value="o242615" serial_no="5" value_object_name="Recordings from membrane patches of dendrites and soma reveal fast and slow responses to fast application of glutamate, mediated by AMPA amd NMDA receptors, respectively " />
        </object>
      </data_class>
    </data_database>
  </data>
</edsp>

