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          <att_value att_id="a366" value="The opening of the Alzheimer's Abeta channel permits the flux of calcium into the cell, thus critically disturbing intracellular ion homeostasis. Peptide segments which include the characteristic histidine diad, His13 and His14, efficiently block the Abeta channel activity blocking Abeta cytotoxicity. Compounds that are known to have histidine association capacity, such as Ni(2+), imidazole, histidine and a series of histidine-related compounds were effective at blocking both Abeta channels and preventing Abeta cytotoxicity. The efficiency of protection of histidine-related compounds was correlated with the number of imidazole side chains in the blocker compounds.&#xD;&#xA;&#xD;&#xA;Efficiency of histidine-associating compounds for blocking the Alzheimer's A{beta} channel activity and cytotoxicity.Arispe NJ, Diaz JC, Flora M. Biophys J. 2008 Aug 22.&#xD;&#xA;&#xD;&#xA;&#xD;&#xA;" />
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