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          <att_value att_id="a366" value="Simakova, O., &amp; Arispe, N. J. (2007). The cell-selective neurotoxicity of the alzheimer's abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for abeta toxicity. J Neurosci, 27(50), 13719-13729.&#xD;&#xA;The response to Abeta by the cells with high Abeta binding affinity was characterized by a larger calcium response and increased mortality, lactate dehydrogenase release, caspase activation, and DNA fragmentation. This selective Abeta binding was correlated to distinctive cell characteristics, such as cell membrane exposure of the apoptotic signal molecule phosphatidyl serine, larger cell size, the G1 cell cycle stage, and a lower than normal cytosolic ATP level. " />
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