<?xml version="1.0"?>
<edsp version="3.1" about_me="http://ycmi.med.yale.edu/EAVCR/EDSP" source="Olfactory Receptors Database">
  <source>
    <type>eav/cr</type>
    <name>Data Store:SenseLab</name>
    <location>ordb.biotech.ttu.edu</location>
    <date>4/4/2026 4:48:50 PM</date>
    <query_method>GET</query_method>
    <query_parameter>o=114239</query_parameter>
  </source>
  <metadata type="partial" time="0.0156208000043989">
    <datatypes>
      <datatype id="B" name="Boolean" xml_datatype="xs:boolean" />
      <datatype id="C" name="Object/Ref" xml_datatype="xs:long" />
      <datatype id="D" name="Datetime" xml_datatype="xs:dateTime" />
      <datatype id="F" name="Formula(only)" xml_datatype="xs:anyType" />
      <datatype id="H" name="Hierarchy(p)" xml_datatype="xs:long" />
      <datatype id="I" name="Integer" xml_datatype="xs:long" />
      <datatype id="M" name="Memo" xml_datatype="xs:string" />
      <datatype id="R" name="Real" xml_datatype="xs:double" />
      <datatype id="S" name="String" xml_datatype="xs:string" />
      <datatype id="V" name="Object/Value" xml_datatype="xs:long" />
      <datatype id="W" name="Object/Ref(MC)" xml_datatype="xs:long" />
      <datatype id="Y" name="Binary" xml_datatype="xs:base64Binary" />
    </datatypes>
    <metadata_ontology>
      <sem_type_atts />
      <sem_rel_types>
        <srt id="s1" umls_tui="QB" name="Class qualifies Attribute" />
      </sem_rel_types>
      <sem_rel_att>
        <sra id="s1" umls_tui="T186" name="is a" />
      </sem_rel_att>
    </metadata_ontology>
    <database id="d14" name="brainpharm" caption="Brain Pharm" caption_long="Brain Pharmacology Database" description="A database to support research on drugs for treatment of different neurological disorders. It enables searches for interactions at the level of key molecular constituents, cell compartments and individual cells in normal brain and in nervous disorders." main_class="108" version="6" version_date="2/23/2009 12:23:48 PM">
      <class id="c108" name="pathological_mechanism" caption="Pathological mechanism" description="Class used to describe pathological events, drug actions, and hypothesis ..." object_description_hide="false" type="E" is_concept="false" host_concepts="false" uid="" version="5" version_date="10/25/2017 12:45:05 PM">
        <att id="a467" dt_id="C" sn="0" name="hypothesis" caption="Hypothesis" description="" ref_class="c141" ref_class_name="hypothesis" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="1" version_date="5/29/2008 12:15:30 PM" />
        <att id="a450" dt_id="C" sn="1" name="pathElemExtracelular" caption="Extracelular pathological element" description="" ref_class="c129" ref_class_name="extracellular_element" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:31:41 PM" />
        <att id="a451" dt_id="C" sn="1" name="PathElemIntracelular" caption="Intracelular pathological element" description="" ref_class="c130" ref_class_name="IntracellularElement" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="5" version_date="5/29/2008 12:15:55 PM" />
        <att id="a354" dt_id="C" sn="2" name="pathologicalAction" caption="Pathological action" description="Pathological action" ref_class="c102" ref_class_name="pathologicalAction" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="5/23/2008 2:32:22 PM" />
        <att id="a465" dt_id="C" sn="3" name="process" caption="Process" description="Neuronal process involved" ref_class="c140" ref_class_name="cell_process" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="5/23/2008 2:32:40 PM" />
        <att id="a466" dt_id="C" sn="4" name="process_action" caption="Process action" description="Action on receptor or channel" ref_class="c139" ref_class_name="process_action" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:34:05 PM" />
        <att id="a357" dt_id="C" sn="5" name="transmitters" caption="Transmitter(s)" description="Transmitter(s) involved in this process" ref_class="c7" ref_class_name="neurotransmitter" mi="false" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="2" version_date="5/23/2008 2:35:21 PM" />
        <att id="a356" dt_id="C" sn="6" name="receptors" caption="Receptor(s)" description="Receptor(s) involved in this process" ref_class="c9" ref_class_name="receptor" mi="true" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:35:32 PM" />
        <att id="a355" dt_id="C" sn="7" name="channels" caption="Channel(s)" description="Channels involved in this process" ref_class="c17" ref_class_name="current" mi="true" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="4" version_date="5/23/2008 2:35:40 PM" />
        <att id="a358" dt_id="C" sn="8" name="pharmacologicalAgent" caption="Pharmacological Agent" description="Pharmacological Agent" ref_class="c103" ref_class_name="pharm_agent" mi="true" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:35:51 PM" />
        <att id="a359" dt_id="C" sn="9" name="pharmacologicalAction" caption="Pharmacological Action" description="Pharmacological Action" ref_class="c104" ref_class_name="pharmAction" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:36:02 PM" />
        <att id="a363" dt_id="C" sn="10" name="brainregion" caption="Brain region" description="Brain region where this is observed" ref_class="c156" ref_class_name="neuronal_structure" mi="true" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="3" version_date="2/22/2018 9:56:31 AM" />
        <att id="a360" dt_id="C" sn="11" name="neuronType" caption="Neuron" description="Neuron" ref_class="c18" ref_class_name="neuron" mi="true" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:37:20 PM" />
        <att id="a361" dt_id="C" sn="12" name="cellModel" caption="Cell model" description="Model Cell used in this investigation" ref_class="c105" ref_class_name="cell_or_modelcell" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="5/23/2008 2:37:37 PM" />
        <att id="a362" dt_id="C" sn="13" name="cellularCompartment" caption="Cellular compartment" description="Event localized to cellular compartment" ref_class="c20" ref_class_name="canonical_compartments" mi="true" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:37:50 PM" />
        <att id="a373" dt_id="S" sn="15" name="pubmedid" caption="PubMed ID" description="" width="20" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="7/11/2006 4:20:39 PM" />
        <att id="a365" dt_id="C" sn="16" name="citation" caption="Citation" description="Publications where this mechanisms was discussed" ref_class="c107" ref_class_name="citations" mi="true" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="5/23/2008 2:38:28 PM" />
        <att id="a390" dt_id="S" sn="17" name="AlzWeb" caption="AlzWeb" description="" width="20" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="2" version_date="11/8/2006 4:36:18 PM" />
        <att id="a366" dt_id="M" sn="67" name="notes" caption="Notes" description="Notes summarizing this mechanism" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="4" version_date="5/23/2008 2:33:22 PM" />
        <att id="a352" dt_id="C" sn="68" name="pathology" caption="Pathology" description="Pathology" ref_class="c100" ref_class_name="clinicaldisorder" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="5/23/2008 2:33:32 PM" />
        <att id="a364" dt_id="C" sn="69" name="stage" caption="Stage" description="Pathological Stage" ref_class="c106" ref_class_name="pathologicalStage" mi="false" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="3" version_date="5/23/2008 2:38:08 PM" />
        <att id="a468" dt_id="S" sn="70" name="question" caption="Question" description="Developer question regarding this entry" width="60" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="3" version_date="10/27/2017 9:53:45 PM" />
        <att id="a473" dt_id="C" sn="71" name="claim" caption="Claim" description="" ref_class="c145" ref_class_name="claims" mi="true" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="2" version_date="4/8/2009 9:32:31 AM" />
      </class>
    </database>
  </metadata>
  <data time="0.0468746999977157">
    <data_database db_id="d14">
      <data_class class_id="c108" version="5">
        <object id="o114239" name="Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e" description="" uid="" version="1" version_date="6/17/2008 11:57:58 AM">
          <att_value att_id="a467" value="o114086" value_object_name="Dendritic Spine Hypothesis" />
          <att_value att_id="a450" value="o97987" value_object_name="beta Amyloid" />
          <att_value att_id="a354" value="o82369" value_object_name="Reduces" />
          <att_value att_id="a465" value="o114237" value_object_name="Dendritic spine motility" />
          <att_value att_id="a358" value="o114046" serial_no="1" value_object_name="Rolipram" />
          <att_value att_id="a359" value="o82370" value_object_name="Blocks" />
          <att_value att_id="a363" value="o186896" serial_no="1" value_object_name="Hippocampus CA1" />
          <att_value att_id="a360" value="o258" serial_no="1" value_object_name="Hippocampus CA1 pyramidal GLU cell" />
          <att_value att_id="a361" value="o92643" value_object_name="Brain slice preparations" />
          <att_value att_id="a373" value="16962789" />
          <att_value att_id="a366" value="Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Mol Cell Neurosci. 2006 Nov;33(3):274-82.&#xD;&#xA;Exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor." />
          <att_value att_id="a352" value="o66226" value_object_name="Alzheimer" />
          <att_value att_id="a364" value="o66237" value_object_name="Early" />
          <att_value att_id="a473" value="o118379" serial_no="1" value_object_name="Loss/alteration of dendritic spines in early Alzheimer's" />
        </object>
      </data_class>
    </data_database>
  </data>
</edsp>

