<?xml version="1.0"?>
<edsp version="3.1" about_me="http://ycmi.med.yale.edu/EAVCR/EDSP" source="Olfactory Receptors Database">
  <source>
    <type>eav/cr</type>
    <name>Data Store:SenseLab</name>
    <location>ordb.biotech.ttu.edu</location>
    <date>4/13/2026 11:39:51 PM</date>
    <query_method>GET</query_method>
    <query_parameter>o=111233</query_parameter>
  </source>
  <metadata type="partial" time="0.0156216999894241">
    <datatypes>
      <datatype id="B" name="Boolean" xml_datatype="xs:boolean" />
      <datatype id="C" name="Object/Ref" xml_datatype="xs:long" />
      <datatype id="D" name="Datetime" xml_datatype="xs:dateTime" />
      <datatype id="F" name="Formula(only)" xml_datatype="xs:anyType" />
      <datatype id="H" name="Hierarchy(p)" xml_datatype="xs:long" />
      <datatype id="I" name="Integer" xml_datatype="xs:long" />
      <datatype id="M" name="Memo" xml_datatype="xs:string" />
      <datatype id="R" name="Real" xml_datatype="xs:double" />
      <datatype id="S" name="String" xml_datatype="xs:string" />
      <datatype id="V" name="Object/Value" xml_datatype="xs:long" />
      <datatype id="W" name="Object/Ref(MC)" xml_datatype="xs:long" />
      <datatype id="Y" name="Binary" xml_datatype="xs:base64Binary" />
    </datatypes>
    <metadata_ontology>
      <sem_type_atts />
      <sem_rel_types>
        <srt id="s1" umls_tui="QB" name="Class qualifies Attribute" />
      </sem_rel_types>
      <sem_rel_att>
        <sra id="s1" umls_tui="T186" name="is a" />
      </sem_rel_att>
    </metadata_ontology>
    <database id="d1" name="neurondb" caption="NeuronDB" caption_long="Neuron Database" description="NeuronDB provides a dynamically searchable database of three types of neuronal properties: voltage gated conductances, neurotransmitter receptors, and neurotransmitter substances. It contains tools that provide for integration of these properties in a given type of neuron and comparison of properties across different types of neurons." main_class="18" version="7" version_date="3/3/2009 11:41:40 AM">
      <class id="c131" name="NCE" caption="Neural compartmental extracell" description="Pathological interactions of extracellular elements to specific neuron-compartmental-properties" object_description_hide="false" type="A" is_concept="false" host_concepts="false" uid="" version="4" version_date="1/17/2008 11:34:06 AM">
        <att id="a445" dt_id="C" sn="0" name="ionChannel" caption="Ion channel" description="Affected/involved ion channel(s)" ref_class="c17" ref_class_name="current" mi="false" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="2" version_date="12/7/2007 1:41:03 PM" />
        <att id="a446" dt_id="C" sn="0" name="receptor" caption="Receptor(s)" description="Affected/involved receptor(s)" ref_class="c9" ref_class_name="receptor" mi="false" is_concept="false" host_concepts="true" srt_id="s1" sra_id="s1" version="1" version_date="12/7/2007 1:38:04 PM" />
        <att id="a429" dt_id="C" sn="1" name="neuron" caption="Neuron" description="" ref_class="c18" ref_class_name="neuron" mi="false" required="Yes" is_concept="false" host_concepts="true" srt_id="s" sra_id="s" version="1" version_date="7/18/2007 12:41:44 PM" />
        <att id="a430" dt_id="C" sn="2" name="CF_Compartment" caption="CF-Compartment" description="" ref_class="c20" ref_class_name="canonical_compartments" mi="true" is_concept="false" host_concepts="true" srt_id="s" sra_id="s" version="2" version_date="12/20/2007 12:09:04 PM" />
        <att id="a431" dt_id="C" sn="3" name="ExtracellularElement" caption="Extracellular element" description="" ref_class="c129" ref_class_name="extracellular_element" mi="false" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="7/18/2007 12:46:45 PM" />
        <att id="a432" dt_id="C" sn="4" name="AffectedInDisease" caption="Affected in disease" description="" ref_class="c100" ref_class_name="clinicaldisorder" mi="false" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="2" version_date="7/18/2007 12:51:19 PM" />
        <att id="a433" dt_id="M" sn="5" name="referencesNotes" caption="References/notes" description="" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="2" version_date="7/18/2007 1:03:21 PM" />
        <att id="a440" dt_id="C" sn="6" name="URL" caption="URL" description="Select a URL from the NeuronDB list of URLs.  Additionally supply a query string if appropriate in the query string attribute." ref_class="c133" ref_class_name="URL" mi="false" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="10/31/2007 2:23:08 PM" />
        <att id="a441" dt_id="S" sn="7" name="query" caption="Query String" description="Supply any query string for use with a NeuronDB.URL here.  The question mark is automatically supplied however the ampersands should be included in the value." width="100" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="10/31/2007 2:24:57 PM" />
      </class>
    </database>
  </metadata>
  <data time="0.0312521000014385">
    <data_database db_id="d1">
      <data_class class_id="c131" version="4">
        <object id="o111233" name="Abeta peptides block LTP in rat CA1 in vivo" description="" uid="" version="1" version_date="1/17/2008 11:36:35 AM">
          <att_value att_id="a429" value="o258" value_object_name="Hippocampus CA1 pyramidal GLU cell" />
          <att_value att_id="a430" value="o290" serial_no="1" value_object_name="Axon fiber" />
          <att_value att_id="a430" value="o293" serial_no="2" value_object_name="Distal apical dendrite" />
          <att_value att_id="a430" value="o294" serial_no="3" value_object_name="Middle apical dendrite" />
          <att_value att_id="a430" value="o295" serial_no="4" value_object_name="Proximal apical dendrite" />
          <att_value att_id="a430" value="o297" serial_no="5" value_object_name="Distal basal dendrite" />
          <att_value att_id="a430" value="o298" serial_no="6" value_object_name="Middle basal dendrite" />
          <att_value att_id="a430" value="o299" serial_no="7" value_object_name="Proximal basal dendrite" />
          <att_value att_id="a430" value="o300" serial_no="8" value_object_name="Soma" />
          <att_value att_id="a430" value="o302" serial_no="9" value_object_name="Axon hillock" />
          <att_value att_id="a430" value="o303" serial_no="10" value_object_name="Axon terminal" />
          <att_value att_id="a430" value="o87536" serial_no="11" value_object_name="Distal oblique dendrite" />
          <att_value att_id="a430" value="o87537" serial_no="12" value_object_name="Middle oblique dendrite" />
          <att_value att_id="a431" value="o97987" value_object_name="beta Amyloid" />
          <att_value att_id="a432" value="o66226" value_object_name="Alzheimer" />
          <att_value att_id="a433" value="&quot;The effect of intracerebroventricular (icv) injections of beta-amyloid peptide fragments Abeta[15-25], Abeta[25-35], and Abeta[35-25] were examined on synaptic transmission and long-term potentiation (LTP) in the hippocampal CA1 region in vivo. ... LTP was, however, markedly reduced by Abeta[25-35; 10 nmol] (129 +/- 9%, n = 6, P &lt; 0.001) and blocked by Abeta[25-35; 100 nmol] (99 +/- 6%, n = 6, P &lt; 0.001). ... The Abeta-peptides tested were also shown to have no significant effect on paired pulse facilitation (interstimulus interval of 50 ms), suggesting that neither presynaptic transmitter release or activity of interneurons in vivo are affected. The effects of Abeta on LTP are therefore likely to be mediated via a postsynaptic mechanism. This in vivo model of LTP is extremely sensitive to Abeta-peptides that can impair LTP in a time- ([25-35]) and concentration-dependent manner ([25-35] and [35-25]). These effects of Abeta-peptides may then contribute to the cognitive deficits associated with Alzheimer's disease.&quot;&#xD;&#xA;(Freir DB et al. 2001)" />
        </object>
      </data_class>
    </data_database>
  </data>
</edsp>

