Pathological mechanism

Data

Name Galantamine increases dopamine release in the hippocampus

Description

Hypothesis

Extracelular pathological element Galantamine Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process Cognitive Decline in Alzheimer's Show Other

Process action Increases Show Other

Transmitter(s) Dopamine Show Other

Receptor(s) Nicotinic Show Other

Channel(s)

Pharmacological Agent Mecamylamine Show Other Sulpiride Show Other

Pharmacological Action Opposes Show Other

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 17133263

Citation

AlzWeb

Notes The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems.Wang D, Noda Y, Zhou Y, Mouri A, Mizoguchi H, Nitta A, Chen W, Nabeshima T. Neuropsychopharmacology. 2007 Jun;32(6):1261-71. Galantamine augments dopaminergic neurotransmission within the hippocampus through the allosteric potentiation of nAChRs. The improving-effects of galantamine on the Abeta(25-35)-induced cognitive impairment may be mediated through the activation of, at least in part, dopaminergic systems

Pathology Alzheimer Show Other

Stage Late Show Other

Question

Claim