Pathological mechanism

Data

Name Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element

Intracelular pathological element Drebrin Show Other

Pathological action Is Correlated with Show Other

Process Cognitive Decline in Alzheimer's Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Neostriatum Show Other

Neuron

Cell model Human Post-mortem Study Show Other

Cellular compartment

PubMed ID 16783169

Citation

AlzWeb

Notes Counts, S. E., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006). Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. Journal of Neuropathology and Experimental Neurology, 65(6), 592-601. Levels of DRB, a dendritic spine plasticity marker, were reduced approximately 40% to 60% in all cortical regions in AD compared with normals.In contrast, DRB levels in the superior frontal cortex increased approximately 30% in AD subjects.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other