Version 6

• Release Date: 08/15

• Published in:

• Informatics Structure: Windows 2012 R2 Server, Web EAV/CR version 4.0. SQL Server 2012

• Database Highlights: To review !!!.

• Major changes with this version: C#, Razor, Webhelpers

Version 5

• Release Date: ?/10

• Published in:

• Informatics Structure: Windows 2008 R2 Server, Web EAV/CR version 3.0. Oracle 11g

• Database Highlights: To review !!!.

• Major changes with this version: The .

Version 4

• Release Date: 6/99

• Published in:

• Informatics Structure: WindowsNT web server communicating with an EAV/CR database hosted on a remote Oracle server via Active Server Pages.

• Database Highlights: Public and private database. Contains about 800 Public and 10 Private receptor sequences. Database is organized based on receptor. BLAST and keyword searches are possible as is browsing the data in several different ways. Interconnectivity with the other senselab databases NeuronDB and OdorDB. Ability to associate odor ligands with receptors.

• Major changes with this version: The change in the database structure from relational to EAV/CR. increases flexibility and allows for not obvious associations between ORs and odor molecules. Multi-level receptor descriptor serving as multi-level nomenclature tools are introduced. Insect receptor sequences are added. The olfactory receptors are divided into four classes depending on their sequence (ORLs, CCRs, VNRs and IORs). Laboratories when submit a sequence to the database are supplied with an ORDB name for that sequence of the type: ORL123. OdorDB is released as a companion database (version 0.5).

Version 3

• Release Date: 4/98

• Published in: Skoufos E., Healy M.D., Singer M.S., Nadkarni P.M., Miller P.L. and Shepherd G.S. (1999) Olfactory Receptor Database: A database of the largest eukaryotic gene family Nucleic Acids Research 1:343-345

• Informatics Structure: WindowsNT web server communicating with a relational Microsoft Access database via Active Server Pages.

• Database Highlights: Public and private database. Contained about 450 Public and 10 Private receptor sequences. Database was organized based on receptor. BLAST and keyword searches are possible as is browsing the data in several different ways. Because of the new informatics architecture the database can operate from a 100 MB zip disk.

• Major changes with this version: Adaptation of a different informatics structure that increased the flexibility and portability of the database. Vomeronasal and c. elegans sequences are introduced. Chromosome localization data for each receptor are introduced. Genome project sequences are added to the database. The ORDB user group is created to further support its users.

Version 2

• Release Date: 4/97

• Published in: Skoufos E., Healy M.D., Smith J.E., Singer M.S., Nakardi P.M., Miller P.L. and Shepherd G. M. (1997) Olfactory Receptor Database version 2: An improved tool for the analysis of the molecular properties of the olfactory receptor molecules. Chemical Senses, 22:794-795

• Informatics Structure: UNIX httpd web server communicating with a relational SYBASE database via WDB and Perl scripts.

• Database Highlights: Public and private database. Contained about 250 Public and 100 Private receptor sequences. Aa and nucleotide entries of each receptor are unified. Database was organized based on receptor. BLAST and keyword searches became possible.

• Major changes with this version: Adaptation of a user-friendly web interface based on frames. Linking at the receptor level to Genbank, Medline and other GPCR database entries. Inclusion of information of source tissue; seperation of source lab (where did we find the receptor) from sequencing lab (who sequenced the receptor).

Version 1

• Release Date: 10/96

• Published in: Healy MD, Smith JE, Singer MS, Nadkarni PM, Skoufos E, Miller PL, and Shepherd GM (1997). Olfactory Receptor Database (ORDB): Resource for Sharing and Analyzing Published and Unpublished Data. Chem Senses Jun; 22 (3): 321-326

• Informatics Structure: UNIX httpd web server communicating with a relational SYBASE database via WDB and Perl scripts.

• Database Highlights: Public and private database. Contained about 150 Public and 100 Private receptor sequences. Separate entries for aa and nucleotide sequences of each receptor. Database was organized based on source laboratory. BLAST searches were possible.

• Major changes with this version: The Public database has informative content. Creation of ORDB link pages. Linking to the other databases of the GPCR database consortium. Inclusion of information of organism, size of clones and Genbank accession numbers.